Word: azt
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Right now, the Center's researchers areinvolved in several projects. Many of them arestill conducting extensive tests on AZT, thehighly touted drug that has been shown tochemically block the AIDS virus from replicating.Other researchers at the Center are working on anew generation of drugs, which work directly onthe virus' gene structure, Groopman says...
...Hill cemetery and caught his foot in the mower; another who was cleaning the meat-slicing machine at a restaurant and cut off his fingertip. A 40-year-old man with black hair and gray skin is complaining of sharp stomach pains. He is HIV positive and taking AZT. "That's what someone looks like who's going to die soon," Dr. Michael Bourland explains quietly as he moves on. Doctors here agree that they make the vast majority of their decisions within the first 15 seconds of seeing a patient. But some things simply demand more time. When...
...worry about the dangers of releasing relatively untested drugs to a broader population, the FDA made a controversial decision last year to allow wide distribution of certain drugs that are still in the testing phase. Among the first was DDI, or dideoxyinosine, an unproven medicine dubbed by its enthusiasts "AZT without tears." The reference is to the most commonly used anti-AIDS drug, which can produce distressing side effects...
...feel the most likely explanation is a simple one: the 8,000 people receiving the drug under the alternate program were sicker than those in the clinical trials. To be eligible for DDI in the expanded tests, patients must be suffering from advanced AIDS and must be resistant to AZT. "For these people, DDI is a last-ditch effort," says Dr. Bernard Bihari of the Community Reseach Initiative, a clinic offering the drug to AIDS sufferers in New York City. Dr. Anthony Fauci of the National Institutes of Health observes that the death rate was much lower than that found...
...drugs are shown to be somewhat effective, the AIDS lobby pushes for their immediate release. To overcome bureaucratic delays, some activists have launched so-called underground testing of drugs that have been of questionable value. The lobby's greatest influence has been at the Food and Drug Administration. AZT, for example, won Government approval in less than four months, compared with a current average of two years. Says James Todd, senior vice president of the American Medical Association: "It's distorted all the traditional principles for drug approval. Penicillin couldn't get through that fast." While some modification...