Word: azt
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Despite the high hopes raised among AIDS patients by the experimental drug AZT, the panel predicts that development of a safe, effective drug to halt or cure the disease or a vaccine that would prevent infection looks to be at least five years away. The time could be even longer, the panel said, if efforts are not stepped up greatly now. In France, however, some AIDS researchers appear more hopeful. Dr. Marc Girard of the Pasteur Institute in Paris announced last week that a vaccine developed there should be ready for human trials sometime next year. The vaccine was developed...
...twelve medical centers around the nation. The centers are awaiting the imminent FDA approval of the drug for use on those whom it seems to help most, the 6,000 AIDS patients who have also suffered a recent attack of Pneumocystis carinii pneumonia. Interim results of clinical trials with AZT were so promising that the tests were halted in September for ethical reasons, so that the drug would no longer be withheld from a control group of AIDS patients who had been receiving only inert placebos. AZT is also the first of the experimental drugs that can successfully penetrate...
...AZT is not a panacea for AIDS. Because the original trials were terminated after only seven months, doctors cannot predict how long doses of the drug will continue to thwart the virus. They also warn that AZT has damaged the marrow of some patients' bones and could have even worse long- range effects. Moreover, says Terry Beirn of the American Foundation for AIDS Research, "we're not talking about cure. At the moment, I don't think it's in the lexicon...
...matter how effective drugs such as AZT and others currently being tested prove to be, they represent only one part of a three-pronged attack on AIDS. Bolstered in June by $100 million in federal funds, Government and industry scientists are also scrambling to develop therapies to help rebuild immune systems devastated by the AIDS attack. "The real goal," says Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases (NIAID), should be "to simultaneously suppress the virus and build up the immune response in the patient." Other researchers are concentrating on preventing the disease, experimenting with vaccines...
...appears to be as effective as AZT, but at least 10 times--maybe up to 100 times--less toxic," said Dr. Raymond F. Schinazi, a virologist at Emory...