Word: azt
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...Washington, the Food and Drug Administration Tuesday approved widespread clinical use of AZT, a drug that checked some symptoms of the disease in limited testing...
After small-scale tests showed that AZT, or azidothymide, appeared to increase the life expectancies of AIDS victims, including patients treated at three Harvard-affiliated hospitals, the FDA agreed to classify AZT as an "investigational new drug," making it available to thousands of patients nationwide...
...Atlanta, medical researchers announced yesterday that they may have developed another drug that works as effectively as AZT without many of its adverse side effects...
...case. But at week's end AIDS researchers were stressing that the study was terminated too soon to learn if the drug prolongs life for more than just a few months or if it has any serious long-term side effects. And they were confident that AZT is not the ultimate weapon against AIDS, that other, more effective drugs will come along. "This is not the end of the story," says Jerome Groopman. "It's exciting to have a drug that appears to benefit patients with AIDS, but there's a lot more work that has to be done...
When word of the early success with AZT began circulating in the medical community, it set off a debate over further AIDS testing. If the drug seemed to slow the progress of the disease, some researchers asked, was it ethical to conduct tests in which half the patients got placebos and thus had no chance to benefit from the treatment? Albert Jonsen, a professor of ethics at the University of California, San Francisco, concedes that the placebo question is "an agonizing problem," but he insists that placebos are the only way to find out "whether there is an effect that...