Word: azt
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...anti-viral drugs are on the cutting edge of Hirsch and Groopman's research. They are azidothymidine (AZT), a synthetic drug that was originally designed to combat cancer, and alpha interferon, a relatively new, genetically-engineered substance. Hirsch has just concluded a two-year placebo-controlled, double-blind study of 24 AIDS and ARC patients treated with the interferon, whose results will be revealed in June. In addition, both Hirsch and Groopman are participating in a nation-wide study of AZT in AIDS and ARC patients. Hirsch has already enrolled more than 100 patients, while Groopman is in the process...
Scientists hope AZT will interrupt this process by preventing the HTLV-III virus from latching onto the genetic material and multiplying, while they hope alpha interferon will keep the viruses from leaving the white blood cell and attacking others. Hirsch is hopeful about the two drugs, both of which have already been shown effective in the laboratory. But there are some indicators that AZT may hold more promise, he and others...
Unlike alpha interferon, AZT can pass through the blood-brain barrier and counteract HTLV-III viruses that have invaded the brain. This may be vital to any successful anti-viral substance that is developed, Hirsch says, because otherwise the virus will simply sequester itself in the brain, the spinal cord, and the peripheral nerves. However, he says that alpha interferon--which is known to be useful in combatting some AIDS-related cancers--may prove valuable in combination with other anti-viral drugs. "[AZT] may turn out to be more useful," he says, "although I don't think we should jump...
...However, AZT has disadvantages of its own, says Dr. Richard G. Marlink, a research fellow in Groopman's laboratory. To be effective AZT must be taken orally every four hours continuously. "Even if it's having any effect, it may be something a patient will have to use the rest of his life," Marlink says. Still, alpha interferon and AZT, are the two most promising drugs around at present, better than those researchers--including Groopman--have tested before such as the much-touted suramin, Marlink says...
...Visszaterve tehat kundulasi pontunkra, csak azt tartjuk halas es sikerrel biztato eljarasnak, mely eszmeivel nem brillirozni akar, hanem a letezo viszonyokat osmerve es szamba veve, azok javitasan faradozik." Which is to say an extreme frigidity generally prevails...