Word: bacitracin
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Dates: during 1950-1959
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Every week U.S. physicians are being bombarded with samples and ads of prefabricated antibiotic combinations-penicillin with novobiocin, neomycin with bacitracin, oleandomycin with tetracycline, and dozens more. In addition, antibiotics are offered in combination with the sulfas or with unrelated items-anti-histamines, hormones, vitamins. Just how good are these package drugs...
...Healer. A plastic adhesive bandage impregnated with streptomycin, polymyxin and bacitracin is being test-marketed by Multibiotics Corp. of Baltimore. Called "Bio-Band," the bandage has been approved by the Food & Drug Administration for over-the-counter sale, is the first bandage treated with wonder drugs available without a prescription...
...record, he was right. As the convention proceeded, there were optimistic reports of a new antibiotic, tetracycline (like aureomycin but with hydrogen replacing a chlorine atom in the molecule), and of a multibiotic. a triple-threat combination of streptomycin, bacitracin and polymyxin, for external use only. But there was also plenty of talk of deleterious effects. Boston's Dr. Ethan Allan Brown called today's enthusiastic but haphazard use of antibiotics "appalling." It is misleading, he said, to speak only of patients whose deaths are recorded as resulting from reactions to antibiotics. There are more deaths, said...
Researchers at the University of California have found that there are about as many cases of antagonism between the drugs as there are of cooperation. By & large, they report, any two of four antibiotics in Group I-penicillin, streptomycin, bacitracin and neomycin-work well together. Except in rare cases, however, none of these four should be used with an antibiotic from Group II: aureomycin, Chloromycetin, terramycin. And while no great harm may come of combining two antibiotics within Group II, no real advantage can be expected either; the combination simply works like a bigger dose of either drug alone...