Word: baclofen
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They call it "the switch." Alcoholics who take an anticraving medication called baclofen say the drug allows them to resist the most powerful triggers of relapse: former drinking buddies, a favorite bar, the sight of alcohol or even the most potent drinking cue of all, having a single drink...
...identified by his real name, experienced his switch at a dinner party two years ago. Bob had battled alcohol dependency for several decades, regularly drinking at least 35 beers a week. Normally he would have downed several glasses of wine before dinner, he says, but that night, after taking baclofen for two weeks, he found himself sipping soda water instead, engrossed in conversation. "I realized I wasn't having that nagging feeling in my head, 'I should really get a drink,'" says Bob. "It never appeared during the dinner either so that was the eureka moment." He continues to take...
...publicized memoir The End of My Addiction (Farrar, Straus and Giroux, 2009). A longtime alcoholic, Ameisen had checked into various rehabilitation centers at least eight times and attended nearly 5,000 Alcoholics Anonymous (AA) meetings, without being able to maintain sobriety. More than five years ago, he began taking baclofen, and since then, he says, he has consistently been able to abstain from drinking altogether or drink moderately in social situations, without having cravings or other addiction-related problems...
Despite such anecdotal successes, so far there is little scientific data in humans to support them. Past studies in animals suggest that baclofen does have a powerful anticraving effect, however, and two large, randomized controlled trials of high doses of baclofen are under way. Meanwhile, more and more American doctors are prescribing baclofen for their alcoholic patients, based on experiences like Ameisen's. And yet even if the apparent anti-addiction benefits of the drug - which is currently approved by the government to treat muscle spasms - are borne out in human trials, it might do little to persuade most American...
...faster fix for substance abuse. New York cardiologist Dr. Olivier Ameisen -who now lives in France but remains a visiting professor at the State University of New York - has authored a new book describing his recovery from alcoholism, which was achieved with the aid of a common drug called baclofen, a muscle-relaxant designed to prevent the spasms behind a range of conditions from hiccups to multiple sclerosis symptoms. The claim is drawing a lot of attention, but it is too soon to say how effective the drug will be for other alcoholics or how widely it will be embraced...