Word: bacterias
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...proposal was based on previous work by graduate student Remy P. Chait showing that, in some cases, using certain types of drug combinations can make it unfavorable for the bacteria to become resistant to one of the drugs in the combination...
...example, if a bacteria is treated with two drugs, A and B, and becomes resistant to drug A, then drug A is no longer an effective treatment. But if drug A suppresses some of the effect of drug B, then developing a resistance to drug A might allow drug B to become more potent, thus having an overall deleterious effect on the bacteria. In effect, Kishony said, “getting beat up by one is worse than getting beat up by both...
...Kishony and Chait had previously hypothesized that bacteria that became resistant to two drug that were known to suppress each other would not fare as well...
...Under Chait’s plan, researchers would spot various small molecules on petri dishes that contain mixtures of bacteria that are either sensitive or resistant to a particular drug. The sensitive and resistant bacteria would be labeled with different colors, such as green...
...develop an immunity by the time flu season comes around in January. The process doesn't always go smoothly, of course. In 2004, California-based Chiron Corp. had to scrap 48 million doses of the vaccine - half the U.S. supply - when regulators discovered that it had been tainted with bacteria. Americans were urged to reserve shots for the ill or elderly, but so many people opted out of shots that the country actually ended up with a surplus. "That was a rough year," says Bridges...