Word: barnette
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Dates: during 1980-1989
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...chimney spouts black smoke that swirls around the head of Steve Harris, who is kneeling on the house's gray-green roof and raising low-hanging telephone wires. The town is left behind, and the landscape shifts to fields of cotton and soybean. As he approaches the Ross R. Barnett Reservoir, Malone pulls a lever on the floor, cranking a cable that raises the house an extra foot so it just barely clears the side railings. "I've been doing this for 20 years, so I know what will go and where it will go," he boasts. The house fills...
Across town, researchers at San Francisco General Hospital Medical Center are conducting cautious, federally approved Phase 1 toxicity trials with minute dosages of GLQ223, as Compound Q is officially known. But for Barnett, a 37-year-old former radio sales manager, as for thousands of others afflicted with AIDS, precious time is running out. Barnett wants to know if Compound Q works in larger therapeutic doses. He wants to know now. "My options are death and doing this," he says...
...Barnett is one of 51 AIDS patients who, along with six doctors, took part in underground trials of Compound Q this past spring and summer. The clandestine study was organized by Project Inform, a San Francisco-based group of activists who believe the Food and Drug Administration's system for testing potentially life-saving new drugs is unconscionably slow. On Sept. 19, Project Inform director Martin Delaney revealed the preliminary results of the underground trials to an intent crowd of some 500 predominantly gay men in San Francisco. Although many of the trial's volunteers, including Barnett, showed a marked...
...some as high as 17 times the dosage given patients in the San Francisco General Hospital toxicity trials. For the first 48 hours, the carefully monitored volunteers suffered side effects of sore muscles, nausea, fever and fatigue. The side effects eventually went away, and many patients, including Bob Barnett, began to feel more energetic...
...such experimental AIDS drugs as r-erythropoietin, which is used to treat AIDS- related anemia, before studies have been completed. Compound Q faces much more rigorous testing despite the hint of promise. "It's not a one-shot cure," Delaney warned the packed community meeting. But Bob Barnett, a true believer in his right to receive another dose of Compound Q, leaped to his feet with the rest of the crowd to give Delaney a standing ovation...