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Cytologists (cell scientists) had known since the early 1900s that some animal cells studied under the microscope contain a little dark spot that others lack. Yet not until 1949 did Canadian Neuro-Anatomist Murray L. Barr realize that the spots, which he was studying in cats' nerve cells, appear only in cells from females. Later research showed that the spots, now known as "Barr bodies" or sex chromatin, consisted of one X chromosome - the one that is inactivated after it has done its job of helping to determine femaleness...

Author: /time Magazine | Title: Cancer: The Significance of a Dark Spot | 3/19/1965 | See Source »

Could it be, they wondered, that Barr bodies might somehow account for the varying reactions to hormone therapy? First they had to find out whether there was any difference in the Barr bodies of different cancer patients. Dr. Hienz discovered that cancer cells from about two-thirds of the breast-cancer cases he was studying contained a normal quota of Barr bodies. But in cells from the remaining third of the patients he could find few or no dark spots. The absence of Barr bodies in some of the cancer cells suggested that those cells had been, in effect, partly...

Author: /time Magazine | Title: Cancer: The Significance of a Dark Spot | 3/19/1965 | See Source »

Wanted: 1,000 Cases. Dr. Ehlers took the next step and traced the histories of 114 patients for any correlation between Barr's dark spots and the effects of testosterone. In general, those whose cancer cells contained Barr bodies did far better on testosterone than similar cases not treated with the hormone. Survival rates were good among Barr-negative patients who did not get testosterone. But the Barr-negative patients who took the hormone survived, on the average, a much shorter time. A Vienna study of 201 patients produced similar results. But the cautious German and Austrian researchers still...

Author: /time Magazine | Title: Cancer: The Significance of a Dark Spot | 3/19/1965 | See Source »

...Like many bankers, he blamed bank takeovers by unsavory characters on a loophole in federal law (since closed) that left federal officials in the dark about changes in bank ownership. Mindful of congressional cries that gangsters may still be buying up banks to sanitize their hot money, Joseph W. Barr, chairman of the Federal Deposit Insurance Corp., announced that he has set up a unit to help the Justice Department weed out criminals in banking...

Author: /time Magazine | Title: Banking: A Bit of Embarrassment | 3/19/1965 | See Source »

...avant-garde is suffering from intellectual hemophilia. It seems temporarily bled out of fresh ideas. The off-Broadway enterprise called Theater 1965, run by Producers Clinton Wilder and Richard Barr and Playwright Edward Albee, is trying to supply some new blood by professionally producing experimental work by young U.S. dramatists, but except for scattered, fitfully exciting moments, the points of view are derivative, repetitive and predictable...

Author: /time Magazine | Title: Theater: The Trouble with Inbreeding | 3/12/1965 | See Source »

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