Word: barriers
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There is an expression in Brazil--dar um jeito--that, loosely translated, means no problem is unsolvable and no barrier too great to cross. Dr. Randas Jose Vilela Batista adopted this attitude in dealing with the patients in his tiny rural hospital outside Curitiba, in the south of Brazil. Many of them were dying of congestive heart failure, which caused their hearts to weaken and enlarge. Because he lacked the resources necessary for the standard American treatments for the disease--drug therapy and heart transplant--Batista needed to come up with a different solution. The one he finally adopted appears...
Black is best known for his discovery that bradykinin, a natural body peptide, is highly effective in opening the blood-brain barrier by making capillary walls leaky--the way leukotrienes do, he says, only to a greater degree. "The fantastic thing about bradykinin," says Black, "is that it does not open the barrier to the normal brain--only to tumors." By using RMP-7, a synthetic version of bradykinin, Black's team has been able to focus chemotherapy drugs right on the tumors, increasing the effective dose as much as 10-fold. Crucial to RMP-7's success, however...
Another major concern is the loss of fluid. When deep burns cover a large area of the body and the skin no longer provides an effective barrier against infection, the immune system goes into overdrive to ward off invading germs. It floods the injured areas with blood and plasma carrying immune cells, which cause extensive inflammation and swelling. In some cases the swelling is severe enough to interfere with breathing, and the patient must be put on a ventilator...
...YORK: Much is being made of the latest memory chip from those whizz-kids at Intel, unveiled to the world Wednesday. You know, the one that smashes through the innovation barrier known as Moore's Law, the one that promises to make memory technology obsolete every nine months instead of every eighteen ? which is the technological equivalent of running a two-minute mile. But does anyone really care? "The irony of this development," says TIME computer correspondent David Jackson, "is that consumers may not want or need it. As it stands now, the hottest new market in the industry...
...seeps into surgical wounds, destroying skin and bones, poisoning blood, threatening death. For years it could be stopped by penicillin. Then it slowly became resistant to one antibiotic after another until finally only one, vancomycin, remained to subdue all staph strains. Now comes word that even that microbial barrier is falling...