Word: baulieu
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...French professor Etienne-Emile Baulieu and researchers from Roussel Uclaf synthesize RU 486 (mifepristone...
Wire services spread the word around the world, and the press laid siege to his office at Paris' Kremlin-Bicetre hospital, leaving Baulieu somewhat perplexed at the sudden interest. He stresses that the pill would not extend life but might, after further testing, enable people to "age well." Even that possibility remained in doubt, though. In the U.S. Baulieu's comments sparked skepticism at the National Institutes of Health and other medical centers...
...Since Baulieu first encountered DHEA more than three decades ago, it has been scrutinized by many researchers, most extensively by Dr. Samuel Yen, an endocrinologist at the medical school of the University of California at San Diego. In a 1986 study, Yen and a colleague found a correlation between low DHEA levels and death from cardiovascular disease...
...involved giving elderly people small doses of DHEA daily, were published last June in the Journal of Clinical Endocrinology & Metabolism. They showed improved well-being, which Yen defines as "the ability to cope," increased mobility, less joint discomfort and sounder sleep. In the November issue of the same journal, Baulieu reported tests on 57 subjects showing that "DHEAS is a good individual marker" of age. As people age, he says, "everybody's level diminishes. But somebody who has a lot of DHEAS to start with will maintain a fairly high count, while those who had a low level...
...currently giving DHEA to another group of older patients to determine whether it will halt or reverse the natural decline in their strength and muscle mass. Meanwhile, Baulieu plans to analyze blood samples from 600 elderly people, trying to correlate DHEAS levels and general health. And he hopes soon to begin testing small doses of the hormone on as many as 200 volunteers, measuring any changes in memory, behavior, skin and muscle tone, cholesterol levels, cardiac activity and joint pain...