Word: bcg
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Dates: during 1970-1979
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...quarters of the women had estrogen-linked tumors. These patients, as well as the others whose cancers were not connected with the hormone, were divided into three treatment groups: one was given a combination of drugs known as CMF; another CMF and tamoxifen; and the third CMF, tamoxifen and BCG (which is designed to bolster the immune system...
...Doctors have been experimenting with immunotherapy-stimulating the immune system to recognize and combat cancer-for several years. Dr. Carl M. Pinsky of Memorial Sloan-Kettering Cancer Center in New York injected BCG, a live-bacteria anti-tuberculosis vaccine, directly into the lesions of 39 patients with malignant melanoma, a rare form of fast-spreading cancer that starts on the skin. In eight of the patients, there was noticeable regression of at least some of the treated lesions; twelve others had regression in all of the sores injected with the vaccine. Two others fared even better. They have experienced complete...
Several doctors are now using BCG for cancer immunotherapy. Dr. Donald Morton of U.C.L.A. has used BCG to hype up the immune systems of patients suffering from malignant melanoma, a cancer that first appears on the skin and spreads rapidly to other parts of the body; some of his patients have been free of the disease for two years or more...
...Georges Mathé, a leading cancer researcher at the Paul Brousse Hospital at Villejuif, near Paris, has been using BCG since 1964. He administers it as part of a double-barreled approach to treating patients with acute lymphoid leukemia, a cancer of the blood-forming tissues that tends to further depress and obliterate the patient's already weakened immune responses. Mathé begins with chemotherapy, using cell-destroying drugs that kill rapidly proliferating cells (and thus destroy cancer cells more quickly than normal ones) to reduce the size of cancers from billions of cells to 100,000 or so. Then he uses...
...Edmund Klein of Roswell Park Memorial Institute in Buffalo has used BCG to stimulate an immune reaction against malignant melanoma, mycosis fungoides and other cancers that originate on the skin, as well as against such deep-seated tumors as breast cancer. He has also experimented with vaccines made from tumors similar to those of the patient, injecting the substance into cancer victims in the hope of triggering not a general immune reaction but one that is specifically directed against the cancer. Of those patients who responded immunologically, most showed marked improvement...