Word: bcg
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...Drawbacks. A second strong plea for the vaccine is.made in BCG Vaccination Against Tuberculosis (Little, Brown; $7.50) by the University of Illinois' Dr. Sol Rosenthal. With the help of the Pasteur Institute's famed bacteriologist Dr. Camille Guérin, 84, TB Fighter Rosenthal records the disappointments attending early efforts to perfect a TB vaccine, then the surprising success of France's late Dr. Albert Calmette, with Guérin collaborating, in attenuating a strain of tubercle bacilli taken from human patients by growing them in cattle. The trouble was that the vaccine, now universally known...
...objections to BCG are based on doubts of its safety and effectiveness, plus the complaint that it invalidates the tuberculin skin test.* Dr. Carroll Palmer of the U.S. Public Health Service found that among 50,000 young people in Puerto Rico, the vaccine cut TB by only...
...Advantages. Advocates of BCG argue that even a small contribution toward reducing TB is worthwhile, point out that the vaccine was shown in Britain to be 80% effective in cutting down TB among exposed adolescents, a rate comparable to that of most other vaccines now in general use. They feel that the value of the tuberculin test has been exaggerated, that X rays and sputum tests are more important and more reliable. BCG vaccine is not perfectly standardized, but the University of Illinois' Research Foundation has pioneered a freeze-drying process by which the vaccine probably can be shipped...
...elaborate as the famed U.S. Salk vaccine trials in 1954, though not as extensive. In London, Birmingham and Manchester 56,700 high school children of 14 to 15½ took part: 13,300, who reacted negative to the tuberculin test, were left unvaccinated as controls; 14,100 more received BCG vaccine; 6,700 got another type of vaccine, vole bacillus.* Another 22,600 children, all of whom showed positive in tuberculin tests, were left unvaccinated as a second group of controls for comparison...
...years all participants in the test were checked with examinations and X rays. There were no deaths from TB, but 165 cases cropped up. Of these. 64 were in the negative-unvaccinated group, for an annual rate of 1.94 cases per 1,000; 13 were in the BCG group, a rate of .37 per 1,000, and seven were in the vole bacillus group, for a rate of .44. Of particular importance: not one of the TB cases in the vaccinated groups was of the especially dangerous meningeal (brain covering) or miliary (throughout the body) variety. There were 81 cases...