Word: benadryl
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Dates: during 1940-1949
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...Benadryl, used for hay fever and other allergies, may cause drowsiness, nervousness, nausea, shock...
Just marketed, and discussed last week in the Journal of Allergy, was another new hay fever drug called Benadryl. Experiments have indicated that Benadryl is an all-or-none drug; it gives complete relief to some 50% to 85% of allergy victims, helps the rest of them not a bit. When it works, it relieves both rashes and runny noses, sometimes makes patients drowsy, must be taken every few hours in capsule form...
Still another new drug, Pyribenzamine, has given similar results. Like Benadryl, it suppresses allergy symptoms by acting against histamine-a substance which is released in the blood stream and causes tissues to break out as rashes or wet noses (or so the latest allergy theory goes). Anthallan, in contrast, behaves more like ephedrine, the well-known drug which gives relief by shrinking the mucous membranes...