Word: beta-amyloid
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Tanzi and colleagues discovered similarities in function between the Alzheimer’s disease-related protein beta-amyloid, or A-beta, and LL-37, a well-known protein found in the first line of defense in the immune system...
...separate area of research, Xie at Massachusetts General tested another anesthetic, isoflurane, on a culture of human brain cells. (Isoflurane had already been shown to cause cognitive impairment in rats.) He saw a vicious cycle of apoptosis and the accumulation of beta-amyloid protein - the sticky plaques that build up in Alzheimer's patients' brains - among the cells. But in this case, it may have been an excess of calcium that led to cell death. Xie and his colleagues have since found that the Alzheimer's drug memantine, which works by reducing calcium levels inside cells, can slow the rate...
...safe. For the hundreds of companies working on treatments, that means relying on drug trials involving patients who may not even have the disease. "That's why the treatments we have now don't work that well," says Adams. In September, Amorfix announced that its technology can detect aggregated beta-amyloid, the protein fragment that, when gobbed together in the brain, is thought to identify Alzheimer's. With 460 million people worldwide over the age of 65, Adams estimates the market at as much as $5 billion...
Nose drops developed by Harvard Medical School researchers have impeded the development of Alzheimer’s disease in mice, and an anti-Alzheimer’s nasal spray for humans could be on the horizon. While plaques made up of beta-amyloid proteins accumulate in the brains of Alzheimer’s sufferers, the new vaccine allows the immune system to produce antibodies that fight these proteins. In tests that have are detailed in the latest issue of the Journal of Neuroscience, the vaccine significantly diminished plaques on the brains of treated mice. Similar tests on human subjects began...
...study, scientists found that elderly lab rats fed curcumin experienced a reduction in the beta-amyloid proteins found in the brains of Alzheimer's victims. When researchers tested curcumin on human beta-amyloid proteins in a test tube, the chemical blocked the proteins from forming destructive plaques?meaning that curcumin could be useful for treating Alzheimer's, and more importantly, for preventing it. Dr. Greg Cole, the lead researcher, hopes that curcumin could be for Alzheimer's what aspirin has become for heart disease: a simple, safe and affordable preventative. New Delhi-based restaurant consultant J. Inder Singh Kalra...