Word: bextra
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Dates: during 2000-2009
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After three days of contentious discussion, an FDA advisory panel last week recommended that the COX-2 drugs Bextra and Celebrex remain on the market but with certain restrictions. Most panel members favored "black box" warnings on the packages indicating that the drugs raise the risk of heart attack and stroke and are therefore inappropriate for many patients. If the FDA adopts this strategy, it would mean the end of ads like the once ubiquitous "Celebrate!" spots for Celebrex, as black-box drugs may not be advertised directly to consumers. But there was tantalizing news for Rickhoff, Dobbs and other...
...there aren't any cardiac effects, and the biggest problem you have is some constipation," which you can treat. On the other hand, Palmer believes that the COX-2 drugs are much safer in the young than in the old. "I'll bet if you break down all those Bextra, Celebrex and Vioxx studies and look at the age group under 40 vs. the age group over 70, you're going to see dramatic differences." The problem, she says, is that most drug studies treat patients from 18 to 80 as a single group...
Vioxx is one in a new class of drugs called COX-2 inhibitors, which were designed to be safer for treating arthritis pain than over-the-counter remedies like aspirin, ibuprofen and naproxen. Concerns have been raised about another member of the group, Pfizer's Bextra. The safety of Celebrex, the most popular of the COX-2 drugs, will be reviewed in the coming months...
...BEXTRA Like the other COX-2 pain relievers, Pfizer's Bextra doesn't work any better than Advil but may be easier on the stomach. Reports suggest Bextra may sometimes cause blood-pressure problems; Pfizer is working with the FDA to get to the bottom of the matter...
...Percentage of those people who switched to Celebrex or Bextra, Pfizer drugs in the same class whose safety has also been questioned...