Word: bileful
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...cortisone were recognized in 1948, one of the most extensive research programs in medical history has been aimed at finding a real supply of the new wonder drug. The only known way of producing it is through an intricate chemical process of 30-odd steps starting with cattle bile. And the yield is so small that several dozen head of cattle are needed to produce one average daily dose for one patient. But last week Harvard's Professor Robert B. Woodward announced that he had reached the first milestone on the road to making synthetic cortisone from simple chemicals...
Half a century later, a new advertising technique gave the sexagenarian business an added boost. The ominous crow was retired; the slogan became "Wake up your liver bile!" Jingles urged readers and radio listeners: "When you feel sour and sunk, and the world looks punk . . . Take a Carter's Little Liver Pill." Carter's went on to claim that the increased liver bile would enable the pill-taker to overeat and overindulge in "good times" without morning-after regrets, to wake up "clear-eyed and steady-nerved," "feeling just wonderful," and "alert and ready for work." Copywriters combed...
...problem is one of supply. Merck is producing enough Cortone [their trade name for the drug] to care for tens of thousands of patients, but the demand for cortisone involves hundreds of thousands. This demand cannot be satisfied by present methods of manufacture The present starting material is cattle bile an organic substance limited in supply. Before cortisone can be made in sufficient quantities, a new, more plentiful starting material will have to be found...
...neither a fool with a frozen smile, Nor a sad old toad in a cask of bile; He can dance with a shoe nail in his heel, And never a sign of his pain reveal...
Some of Levine's latest paintings gave indication that he was losing a little of his early bile. Cartoons in oil like Reception in Miami and Welcome Home, a prod at Army brass, came a little less frequently. "I may have been angry or bitter but I don't stay that way," explained Levine...