Word: bladder
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...results from a Canadian study linking the sugar substitute with bladder cancer in rats. The Delaney Amendment, which prohibits the addition of any substance to food if studies show the substance to cause cancer in human or animals, requires the bans...
Most saccharin users think the FDA's action is silly, a gratuitous Government act reminiscent of the cyclamate ban more than seven years ago, which left saccharin as the only FDA-approved artificial sweetener. In recent Canadian tests, some rats that were fed enormous doses of saccharin developed bladder cancer. To take in an equivalent amount of saccharin, a human would have to drink at least 800 cans of diet soda every day. Under the law, however, the FDA had no choice: the so-called Delaney amendment of 1958 to the Food, Drug and Cosmetics Act forces...
After recent tests conducted in Canada found that large doses of saccharin caused bladder cancer in rats, the Food and Drug Administration (FDA) proposed a ban on the artificial sweetener to take effect within 120 days...
...Canadian experiment "unequivocally" showed a carcinogenic effect, but there are no reported cases of saccharin-induced bladder cancer in humans in the 70 years that saccharin has been on the market, Brown said...
...effect in July, is based on a study by the Canadian government's health-protection laboratory in Ottawa. For three years, researchers fed rats daily doses of saccharin that amounted to 5% of their diet by weight. In the first generation of rodents, seven out of 38 developed bladder tumors, three of them malignant. In the second generation of rats-which had developed in the wombs of saccharin-fed mothers, were nursed on their milk and later given the chemical themselves-twelve out of 44 had tumors; eight of them were malignant. That was enough...