Word: bladdered
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...three surgeons-Dr. Arthur Waite Bohne, chief of the Department of Urology at Ford, Dr. Paul Jackson Hettle of his staff, and Dr. Robert Wallace Osborn-began experimenting on dogs, succeeded in regenerating completely removed bladders by introducing a plastic mold around which a new bladder could grow. The technique worked so well that they decided to try it on humans...
Instead of a mold, which has to be removed in a second operation, the doctors used a three-by-four-inch. egg-shaped plastic bag. They removed B.C.M.'s diseased bladder, severing the ureters and the urethra where they entered the bladder, and put the inflated bag in its place. A Y-shaped tube ran through the bag. Its two arms were inserted through the dangling ureters to the kidneys and its trunk was passed through the urethra and outside the body through an incision (necessary only in males). This short cut from the kidneys permitted B.C.M. to live...
...sewed up, his body began reacting, building up a thick-walled pouch around the plastic bag. In 30 to 50 days, the pouch had completed the first of three distinct layers of tissue, and at the end of 90 days the smooth muscle tissue that discharges the bladder at will had been formed. Meanwhile, the pouch had adhered to the surrounding body tissues and to the severed ends of the ureters and urethra...
B.C.M. now had a perfectly healthy (although slightly smaller) new bladder. The plastic bag was deflated and, with its tubes, pulled out through the urethra and the incision without further surgery. Since the operation had not touched the small sphincter muscle that opens and closes the entrance to the urethra, the patient had no difficulty in controlling his new bladder...
...smooth muscle in the pouch was, in the words of the doctors, "more difficult to rationalize" : true regeneration of smooth muscle has been observed only in rare situations, and mostly in animals. After considering several possible sources, doctors could only conclude that the smooth muscle in the new bladder may somehow have been formed from the primitive connective tissue...