Word: blocking
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Dates: during 1980-1989
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Paul believes ethanol also reduces anxiety by acting on those GABA-sensitive neurons. Altering the amount of GABA in the brain could theoretically neutralize the effects of intoxication. To that end, Paul is currently experimenting with a drug, Ro15-4513, that blocks ethanol's ability to activate the GABA receptor, thus sharply reducing alcohol's sedative effects in rats. Although the drug is toxic to humans, variants could one day be useful in treatment. Other scientists are studying a new class of drugs that seem to block the alcoholic's craving for a drink. These compounds boost the amount...
Critics accuse Koch of giving away the government to political bosses and giving away Manhattan to developers. Koch has coddled builders with tax breaks while their towering, ego-driven projects block out the sun, overload already groaning services and paralyze traffic. Celebrities like Jacqueline Onassis, Henry Kissinger and Paul Newman have joined hundreds of West Side residents in protests against skyscrapers proposed by Builders Donald Trump and Mortimer Zuckerman. Bowing to public pressure, Zuckerman has offered to scale down his 68-story tower, which would cast shadows across Central Park. NBC has backed away from Trump's proposed Television City...
Boston's Blackstone Block is just such a marvelous chunk of city. Wedged between restored Faneuil Hall Marketplace and city hall, Blackstone Block is a seemingly haphazard labyrinth of buildings from several centuries strung along narrow, zigzagging streets. This jam-packed patchwork is, in extremely concentrated form, the natural look of cities, of anything created over time by many hands. Certain tacit rules apparently governed the 250-year accretion of buildings in Blackstone Block -- rules about material (red brick) and height (seven stories maximum) -- but within those constraints houses and workshops were demolished and built as circumstances demanded over...
...Whitmanesque to suggest that it is the hurly-burly pleasures of democracy -- pluralism incarnate -- that pulled Americans back downtown? Old cities are architecturally eclectic places, where Queen Anne turrets bump up against an International Style library. On a single block, even in a single building, people work as well as live as well as shop. In good cities, infants in Apricas share sidewalks with octogenerians, Salvadoran immigrants with manicured executives. In good cities, eras and generations and races and pursuits are a jumble. Serendipity and surprise are the point...
Stupid Question of the Week: "Were you happy with the save?"--reporter at Sunday's post-game press conference to Hall, referring to his amazing one-fisted block that sent the game into overtime...