Word: bloodstream
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Dates: during 2000-2009
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...Bush with his sports-jock patter made his first postelection visit to Clinton with his rock-star genes, they just clicked. The new guy had no questions about Third World debt. He wanted to know what made the place tick and how you mainline yourself into the nation's bloodstream. Clinton told Bush he was lucky to know already where the light switches were and to have hired people who had been there before. Bush asked Clinton what he thought about Bush's calling him "the Shadow" during the campaign. Had it spooked Gore? Must have, Clinton said; he didn...
...colleagues have launched a project to unravel exactly what--at the genetic level--makes some people benefit from drugs and others not. They suspect that one major factor is a class of proteins called membrane transporters. These proteins act as molecular gatekeepers, deciding which foreign substances in the bloodstream will be taken into and which rejected by individual cells. If, for example, people lack the gene for an inactivating enzyme, says Herskowitz, "a standard dose of a drug will be more potent. If they have an extra copy of the gene, a standard dose will be inadequate...
...opposite end of the technology scale, Eldrid Sequeira, a Utah State University graduate student, is designing microscopic "submarines"--drug-bearing capsules that someday could be propelled through the bloodstream by bacteria to attack disease. Looking even further ahead for alternative means of driving these tiny craft, he is considering building biomotors 100 billionths of a meter wide that would use only the bacteria's hairlike, propelling flagella to move ahead...
...promise of the new drug systems, M.I.T.'s Langer is still looking ahead to what many researchers hold out as an ultimate goal: a magic bullet placed in the bloodstream that "goes right to where you want it and only there, and does exactly what you want it to do and only that. We are not there...
...there, it's hard to get worked up over a toenail fungus or a case of athlete's foot. But the fungi that cause these and dozens of other infections are not as trivial as they may seem. Fungi have a way of turning nasty--seeping into the bloodstream and invading vital organs. Lately they've been doing that more and more, thanks to increased travel (which exposes people to fungi for which they have no immunity) and to immunosuppressant drugs (which leave patients vulnerable to what would otherwise be innocuous fungal infections). "The kind of thing that used...