Word: bloodstreams
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...plain another mystery of penicillin -why it is so much less likely to cause severe reactions when taken by mouth than when injected. It seems that much of the protein impurity is destroyed - digested, in effect - in the alimentary tract before it can get into the bloodstream...
L.S.D. differs from most other drugs because its effects occur at varying periods after the ingestion of the drug. What it does, in effect, is to start in motion processes, as yet not understood, which produce effects after the drug itself has left the bloodstream. There may be severe depressions lasting for several months, or psychotic reactions, or at other times both pleasant and frightening episodes...
...each center. But Physiologist Gregory Pincus of the Worcester Foundation for Experimental Biology and Gynecologist John Rock of Harvard University rate high among the pioneers of oral contraception. It was at Harvard, too, that Dr. Fuller Albright noted in the mid-1940s that an excess of estrogen* in the bloodstream soon after the end of menstruation somehow prevented ovulation. A few years later, Pincus and Rock were working together to find a way of helping subfertile women ovulate, and thus conceive. They first had to regularize the woman's cycle, and they hit upon a synthetic progestin chemically akin...
...Then, instead of replacing her own pancreas and duodenum with the graft, they left her digestive tract intact and implanted the entire new unit in the left iliac fossa, just above the groin. It is hooked up to her arteries and veins, so it spills its hormones into the bloodstream, where they augment the output of her own failing organs...
...Klein figured that with localized application he could keep the drugs out of the bloodstream and use them on skin cancers without any of the dangerous side effects. Cautiously, he injected minute doses between layers of the skin, or applied the drugs in ointments and creams. From the beginning, he got an encouraging and prompt response. Furthermore, a number of the drugs he was testing seemed to sensitize the patients' skin, particularly in the cancerous areas. Subsequent applications then caused a bright red, allergic-type reaction. As the dosage was repeated, the reaction got stronger, and selectively destroyed cancer...