Word: bone-marrow
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...after the trauma of surgery and the misery of chemotherapy is the nightmare of every patient. When this happens, the outlook is grim. But in recent years doctors have been experimenting with a controversial treatment for advanced and recurring breast cancer that involves massive doses of chemotherapy and a bone-marrow transplant. Annette Crossley, 45, of Glendora, Calif., is hoping it will save her life. Crossley suffered a cancer relapse just a few months after completing a course of treatment that included a mastectomy, chemotherapy and radiation. Given slim odds of survival, she chose to try the new treatment...
Anderson and Blaese are confident that gene therapy could fit the bill. Ideally they would prefer to insert ADA genes into bone-marrow stem cells, which would continuously manufacture blood cells containing the gene and ensure a steady supply of the enzyme. But researchers have yet to find a way to isolate marrow stem cells effectively. Instead, the NIH researchers opted for T cells, immune-system cells that can survive in the bloodstream for months and even years...
Jean-Pierre Bosze is not likely to be alive a year from now if he does not receive a bone-marrow transplant. Diagnosed with leukemia in 1988, the 12- year-old boy from Hoffman Estates, Ill., has searched in vain for a suitable donor. His father Tamas, his mother and other relatives have had their blood tested, but none has the right type. His doctors have consulted the National Marrow Donor Program of 180,000 potential donors, but the odds of unrelated people matching...
...child's. But should they create a new life to rescue an endangered son or daughter? A Los Angeles couple, Abe and Mary Ayala, has taken just such an unusual step. In April, Mary will give birth to a baby girl who was purposely conceived to serve as a bone-marrow donor for her ailing older sister. Anissa, 17, was found to have a virulent form of leukemia nearly two years ago, and her only hope is a transplant of compatible bone marrow that could allow her to produce healthy white blood cells. Tests indicate that the baby has compatible...
...ethical dilemmas of creating a child donor could have been avoided if a suitable non-sibling donor had been available. Experts urge that more money and public-education efforts be devoted to expanding the national registry of potential bone-marrow donors...