Word: bone-marrow
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...other life-threatening microbes. Groopman believes GM-CSF could one day be used to treat a variety of diseases. "This is the first time that anyone has been able to regulate the white- blood-cell count in man," he says. "There are implications for cancer patients and people with bone-marrow disorders...
Unfortunately, AZT is not a cure and has a number of serious drawbacks. It must be taken every four hours around the clock to be effective, and can cause severe bone-marrow damage and anemia in some patients. "It's not an answer, and it's very toxic," says Polk, of Johns Hopkins. "Probably half of our patients on AZT will require weekly or bimonthly blood transfusions...
...halting the test robbed researchers of the chance to judge, under controlled conditions, any long-range effects of AZT, which might be as dangerous as the untreated disease. In fact, some people taking AZT have developed anemia and suffered bone-marrow degeneration. "AZT may be a genie that we are letting out of the bottle," says Dr. Itzhak Brook, chairman of the FDA advisory committee and the only dissenter in the vote. Dr. Maxime Seligmann, a French immunologist who has experimented with AZT at the Hopital St.-Louis in Paris, agrees: "There simply isn't enough knowledge about the benefits...
...their family's medical catastrophes. The scientific evidence may be statistical rather than empirical, but it is convincing. Lieut. Zumwalt seems inclined to take it as it comes. His childhood illnesses may have taught him valuable lessons about physical and psychological courage. He endures radiation, chemotherapy and painful bone-marrow transplants that slow but do not stop his cancers. Most of the news he gets from his doctors is bad. "I really had to work on myself mentally to avoid sadness and depressions, . . ." he writes. "I began to see my illness as a process of diminishing expectations and choices...
...actually harmful. Eager for any hopeful note, some reporters at the conference seized upon and overplayed a report by Dr. Anthony Fauci of the National Institutes of Health. Fauci revealed that one of his AIDS patients had regained his health and returned to work after treatment that included a bone-marrow transplant from his identical twin. Whether the patient has been permanently cured remains in doubt, and two other victims who received the same therapy have not improved. Fauci himself pointedly refrained from characterizing the procedure as a success, saying, "This is not a breakthrough, (just) a small but important...