Word: bone-marrow
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...None of his three companions-Françoise Giroud of L' Express, Pierre Viansson-Ponté of Le Monde and Roland Faure of L 'Aurore-used the information directly or indirectly while Pompidou lived. Nor did Giroud publish the news that Pompidou was suffering from multiple myeloma (bone-marrow cancer), a fact she had learned prior to the lunch last spring...
Presented by Good and his group in the mid-'60s, the "two component" theory became the foundation of modern immunology, and led to new experiments and ways to understand the phenomenon of immune response. It also led to another of Good's contributions ?the first successful use of bone-marrow transplants to correct immunodeficiency disease...
...Doctors had experimented with bone-marrow transplants in the mid-'50s, primarily to combat leukemia. But their efforts proved generally unsuccessful. Immunologically sound bone marrow contained cells that recognized the recipient of this gift as "foreign." The new cells, in a phenomenon known as "graft v. host" reaction, thus rejected the host, producing lymphocytes capable of reacting with and destroying his tissue. In fact, the reaction, combined with infection and other factors, could prove fatal to the recipient whose immune system was either weak or absent...
...year-old Mrs. Myrtle Joseph of Youngstown, Ohio, was examined by Dr. O. Whitmore Burtner, now of Miami. A bone-marrow test indicated that she suffered from chronic lymphatic leukemia, which was spreading slowly. By 1964, Mrs. Joseph needed regular blood transfusions. Her liver, spleen and lymph nodes became swollen. Then, in May 1967, she wrote a letter to Kathryn Kuhlman asking for her prayers. Within a few days she felt so well that she stopped seeing Dr. Burtner. Alarmed, he asked her to come in for tests. Her marrow, liver, spleen, lymph nodes and white blood cells were normal...
...blaming LSD directly for the abnormalities. "The association between the ingestion of lysergide and the occurrence of acute leukemia may be casual rather than causal," they wrote, "but certain unusual features in our case suggest that it may be causal." Among these features were the patient's unusual bone-marrow chromosome pattern and the presence of large cells containing multiple micronucleoli. Dr. Lionel Grossbard and colleagues at Columbia's College of Physicians and Surgeons, who reported the case of the U.S. college student in the A.M.A. Journal, were somewhat more cautious in their conclusions. Further evidence is needed...