Word: bone-marrow
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...cells, which normally patrol the body looking for foreign invaders like bacteria, viruses and tissues from outside donors. Several days before the transplant surgery, Sachs' team used drugs that target and eliminate these cells to wipe the immune slate clean. Then the team transplanted the kidney along with donor bone-marrow cells. What happened next was surprising: the bone marrow rebuilt the immune system but this time as a chimera?a hybrid of both the donated organ's cells and the body's own. The donated organ could then be accepted instead of rejected...
...original version of this article mistakenly reported that surgeons transplanted a donated kidney along with bone-marrow cells that had been harvested from the patient. In fact, the bone-marrow cells also came from the donor...
...multistep therapy requires doctors to extract bone-marrow stem cells from breast-cancer patients prior to surgery. After the tumor-removal operation, patients are exposed to brutal doses of chemotherapy, then re-infused with their stem cells, which restore immune cells destroyed by the chemotherapy. But ultrahigh doses of chemo are extremely toxic, and in fact, some of the 20,000 women who have received the treatment in the U.S. have died from the toxicity...
...what they have to do. Margaret Mikol is one such hero. In 1978, her daughter Julia was born with severe combined immunodeficiency, which required her to be kept in a completely sterile hospital environment--like the "boy in the bubble." When Julia was 3 months old, she had a bone-marrow transplant that left her with a functioning immune system but unable to breathe on her own. Her hearing was impaired as well. She spent the next two years in the intensive-care unit at Memorial Sloan-Kettering Hospital in Manhattan...
...familiar numbers (47 million uninsured Americans, the ever rising cost of care) and chilling moments (the 18-month-old baby who dies of a seizure when she?s denied emergency-room access, the husband and father with kidney cancer whose insurer won?t pay for a bone-marrow transplant). Together, they will have many moviegoers angry enough to gouge holes in their armrests...