Word: bone-marrow
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Imagine for a moment that your daughter needs a bone-marrow transplant and no one can provide a match; that your wife's early menopause has made her infertile; or that your five-year-old has drowned in a lake and your grief has made it impossible to get your mind around the fact that he is gone forever. Would the news then really be so easy to dismiss that around the world, there are scientists in labs pressing ahead with plans to duplicate a human being, deploying the same technology that allowed Scottish scientists to clone Dolly the sheep...
...John Hinckley Jr. in 1981, Ronald Reagan was closer to death, and slower to recover, than anyone admitted at the time. And in 1992, when Paul Tsongas was a Democratic presidential candidate, he and his doctors said he was free of the lymphoma that led to his 1986 bone-marrow transplant. He died of the disease...
Without dramatic intervention, Molly Nash, 6, who suffers from a blood disorder that leads to dangerously low blood-cell counts and constant fatigue, could have died within a year. Her only hope was a bone-marrow transplant, preferably from a genetically matched sibling...
SURVIVORS An experimental bone-marrow transplant may help treat kidney cancer, a disease so virulent that once it spreads, it kills half its victims within a year. Stem cells--the primordial cells that give rise to new cell lines--are collected from bone marrow. Once transplanted, they generate a new immune system, one that's capable of fighting off the cancer. The technique has been tried on only 19 patients, all terminally ill, but the results are promising. Although 10 died, two from the treatment itself, the others saw their malignancy shrink or completely disappear...
Doctors have successfully treated many young SCID patients before with various types of bone-marrow transplants. What distinguishes these two babies, researchers reported in Science last week, is that they are the first to be treated, apparently successfully, entirely by gene therapy. Says Dr. Alain Fischer, who headed the gene team at Hopital Necker-Enfants Malades in Paris: "Preliminary evidence is of a faster and more complete immune reconstitution after gene therapy...