Word: bone
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Dates: during 1980-1989
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...woven from vine roots with its mouth outlined in dogs' teeth and its scalp matted with human hair, could coexist with a high order of technical skill. What survived the auto-da-fe in greater quantity was decorative art of lesser iconographic content: not gods, but feather robes, bone or whale-tooth ornaments, and the beautifully carved wooden containers, irregular in their polished silkiness, from which the Hawaiians ate their poi, a sort of tropical office paste made of taro roots...
...medical payoff from it may come a bit sooner. In that experiment, a team of scienlists led by Martin Cline and Winston Salser isolated genes that help produce an enzyme resistant to methotrexate, a drug used to treat cancer. The researchers added the genes to cell cultures of mouse bone marrow. The cells that picked up the foreign material, along with cells that had been incubated with genes that do not confer resistance, were then injected into mice whose own bone marrow had been destroyed. To see if the drug-resistance genes were working, the animals were given methotrexate. Tests...
...U.C.L.A. findings may eventually help patients undergoing cancer chemotherapy. Methotrexate, used to treat leukemia and other cancers, is like most antitumor drugs: potent but harsh. It indiscriminately destroys rapidly proliferating cells, malignant and healthy alike. Among the healthy ones are those of bone marrow, which produce blood cells. The damage that methotrexate does to bone marrow effectively limits how much of it can be given to patients. Making the cells resistant to the drug's assault might give patients the ability to withstand more intensive therapy...
Researchers also speculate that doctors might use the technique to correct blood diseases that result from defects in single genes, including sickle-cell anemia and thalassemia. The therapeutic gene could be transferred into bone marrow cells along with a gene for drug resistance. Exposure to the drug would kill off marrow that produces defective blood cells and allow a population of "cured" cells to take over...
Terry Fox, 22, is a fitness-minded British Columbian who played soccer and basketball at Simon Fraser University near Vancouver-until 3½ years ago, when he learned that he had bone cancer. His right leg was amputated above the knee in March 1977, a blow that seemed certain to rule out further athletic achievement. Yet this summer, Fox caught the imagination of Canadians by attempting an extraordinarily punishing feat as a long-distance runner. On April 12 he set out from St. John's, Newfoundland, intent on running 5,300 miles across the continent to Vancouver...