Word: boning
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Dates: during 1990-1999
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Another problem is getting viral vectors into bone-marrow stem cells, from which all of the blood's white cells are descended. Even when the rare stem cells are found, inserting genes into them is difficult because they divide infrequently, and the vectors used in gene therapy insert genes only into cells that are dividing. Had Anderson's group been able to use stem cells in the landmark therapy with little Ashanthi DeSilva, for example, follow-up treatments would not have been necessary. Endowed with the normal gene, the marrow stem cells would have produced a continuing supply...
...Bone-marrow transplants cured SICKLE CELL ANEMIA in three-quarters of youngsters in a recent study. But the radical procedure will probably be reserved for the worst cases because 10% of the patients died...
...experiment described in the current Nature suggests that the huge carnivore did indeed have the most powerful bite in history. Researchers led by Gregory Erickson, a graduate student at the University of California, Berkeley, figured that if they could reproduce the T. rex bite marks found in fossilized Triceratops bones, they could deduce how much force had been needed to make them. So with the help of Stanford biomechanical engineers they crafted a false Tyrannosaurus tooth out of bronze and aluminum, then mounted it in a guillotine-like device and slammed it into the pelvic bone...
...Jane was working within 1/16 of an inch of the brain stem. He placed a wire under both lamina--the bony covering of the spinal cord. He took bone from Reeve's hip and squeezed it down to get a solid fit between the C1 and C2. Then he put in a titanium pin the shape of a tiny croquet wicket and fused the sublaminal wire with the first and second vertebrae. Finally, he drilled holes in Reeve's skull and passed the wires through to get a solid fusion...
...wound in his sacral area, called a decubitus, began to open. It went so deep, it opened to the bone: "You could go put your hand inside it." His doctors wanted to operate, which would have required grafting skin to the wound, but he asked them not to. He had to agree to stay in bed for eight days without moving. The view he had out his window was of a brick wall. He could see only the wall, but he imagined that above the wall was a roof, and above that a clean sky. "I had this fantasy about...