Word: bradfields
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...Truth, in equal parts political and passionate, picks up where the previous Everything Must Go left off. As you might expect from an album whose first single is called "If You Tolerate This Your Children Will Be Next," it's a dour piece. The wrenching anguish in James Bradfield's voice combines with Nicky Wire's lyrics ("I've got to stop smiling it gives the wrong impression") to create an air of bleakness not unlike the vast empty expanse on the album cover. This slips into pretentiousness at times, such as in the final song "S.Y.M.M." ("South Yorkshire Mass...
...Truth, in equal parts political and passionate, picks up where the previous Everything Must Go left off. As you might expect from an album whose first single is called "If You Tolerate This Your Children Will Be Next," it's a dour piece. The wrenching anguish in James Bradfield's voice combines with Nicky Wire's lyrics ("I've got to stop smiling it gives the wrong impression") to create an air of bleakness not unlike the vast empty expanse on the album cover. This slips into pretentiousness at times, such as in the final song "S.Y.M.M." ("South Yorkshire Mass...
...happened, Bradfield's tumor cells had a characteristic present in about 30% of breast-cancer cells: too many copies of a gene known as HER-2/neu. This gene makes a protein that helps relay the signal telling cells to divide. Having too much of it is associated with an especially rampaging, hard-to-treat cancer. Once this form of breast cancer metastasizes, a patient typically has just six to 12 months to live...
...Bradfield's doctor put her in touch with UCLA's Slamon, who was testing a brand-new antibody that targeted the HER-2/neu protein. Although Slamon was using the antibody in combination with chemotherapy--and Bradfield was loath to go back to chemo--the combined therapy proved miraculous in her case. Sixteen small tumors in her lungs melted away. By 1993 she was in remission, and still is. "I got to be at my son's wedding," she exults. "The gift is that I'm here...
...antibody is not a panacea. It didn't work as well for Bradfield's fellow guinea pigs in the initial study. But results of a just completed trial with 470 women do show it to be a significant improvement over chemo alone for women with this awful form of breast cancer. The details of the study will be revealed by Slamon this Sunday at a meeting in Los Angeles of the American Society of Clinical Oncology. Manufactured by Genentech under the name Herceptin, the drug is on a fast track for approval by the FDA, perhaps before year...