Word: bradykinin
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Dates: during 1984-1984
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...pain message originates at the point of contact (see diagram). It begins with the release of a number of potent chemicals that are normally stored in or near nerve endings for use on just such clumsy occasions. Among these chemicals are the mysterious substance P (for pain), prostaglandins and bradykinin, probably the most painful substance known to man-just a tiny amount inserted under the skin with a needle causes excruciating pain. These substances sensitize the nerve endings and help transmit the pain message from the injured region toward the brain. Prostaglandins also increase circulation to the damaged area, causing...
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