Word: braine
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Dates: during 1990-1999
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...just another routine case," says Dr. Mahlon Johnson. In 1992, as the Vanderbilt University neuropathologist was removing the brain of a man who had died of AIDS, his hand suddenly slipped. The bloody scalpel sliced through his glove and deep into his left thumb. Because of that "freaky little slip of the scalpel," as Johnson ruefully characterizes it, he endured seven "nerve-racking" months. He took several HIV tests--all were negative. Then the result that he had been dreading came in: he was HIV positive...
...academic career to work among the Amish. One of those diseases, he has discovered, is glutaric aciduria, a metabolic deficiency that usually strikes children between the ages of 6 months and 5 years. Often triggered by childhood illnesses such as chickenpox or strep throat, it can cause permanent brain injury that can lead to chronic disability, medical complications and even early death...
...Naomi. But Barbie Ann soon developed a fever, and Morton admitted her to Lancaster General. Stressed by infection, a child with glutaric aciduria does not metabolize certain amino acids normally. The resulting buildup of glutarate attacks the nervous system and damages the basal ganglia, a part of the brain that controls body movement. Once brain injury occurs, a child never recovers. "If it weren't for Dr. Morton and the clinic," Lydia says, "Barbie Ann would have ended up like many of Amos and Suzie Miller's children. Five of them died or are paralyzed because of this disease...
Suppose you are at risk of a genetic disease that threatens to render you unrecognizable to yourself. Physically, you realize, the disease will slowly erode your body to an incontinent mass of uncontrollable jerks and twitches. Mentally, it will eat away at your brain cells, impeding your ability to remember, pay attention, reason. And emotionally, it will blacken your days with irritability and all-consuming depression. Worst of all, you know that the disease cannot be prevented or stalled, arrested or cured. To learn that you have the offending gene is to receive a virtual death sentence that leaves only...
...disorder, Brandt started delving into amnesia, Alzheimer's and dementia while a graduate student at Boston University. Upon joining the Johns Hopkins faculty in 1981, he began focusing on HD, a disease that he says provides "an almost unique opportunity to study how a deterioration of systems in the brain could result in cognitive, emotional and movement problems...