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...cells, leptin helps manage just how much fat you store around your organs and under your skin through a complex feedback loop. If your fat deposits start to shrink--for example, when you lose weight--the amount of leptin in your body falls, a situation that the brain interprets as a result of starvation. The whole system of chemicals and neurological impulses shifts in an attempt to get the body to burn fewer calories so that it can regain the weight. The greater the weight loss, the stronger the signals to eat more and replenish fat stores...

Author: /time Magazine | Title: America's Obesity Crisis:Eating Behavior: Why We Eat | 6/7/2004 | See Source »

There are many other factors that affect this delicate balance. For example, laboratory evidence suggests that a diet that boosts your triglycerides--typically, one high in fatty, fried or highly refined foods--may interfere with both leptin's and insulin's actions on the brain, leading to an erroneous signal that the body is in danger of starving. The same receptors in the brain that are responsible for a marijuana high also boost appetite, which is why pot smokers get the munchies...

Author: /time Magazine | Title: America's Obesity Crisis:Eating Behavior: Why We Eat | 6/7/2004 | See Source »

...build up your biceps ... in order to push yourself away from the table. Then came the discovery in 1995 of genes that regulate leptin, the hormone that controls how much fat your body stores. Since then, scientists have identified dozens of compounds related to weight, some released in the brain and others...

Author: /time Magazine | Title: America's Obesity Crisis:Pills in the Pipeline | 6/7/2004 | See Source »

Scientists are channeling their efforts toward two main targets: the feeding center in the brain, which is supposed to tell the body when to eat and how much, and the myriad signals that originate in the gut and then flow into the brain, triggered by the amount of food you eat. These messages order the body to burn calories right away or store them as fat for later...

Author: /time Magazine | Title: America's Obesity Crisis:Pills in the Pipeline | 6/7/2004 | See Source »

...eating side, researchers at Glaxo are studying cholecystokinin, which is released by the intestines after a meal to signal the brain that the body has had enough. Giving obese patients a synthetic form of cholecystokinin before meals tricks the body into feeling full, so patients eat less. About 25% of the participants in an early trial lost almost 7 lbs. in the first eight weeks...

Author: /time Magazine | Title: America's Obesity Crisis:Pills in the Pipeline | 6/7/2004 | See Source »

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