Word: breakdown
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Dates: during 1960-1969
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Making matters even more complicated, some drugs increase the potency of enzyme activity. This leads to the bizarre situation in which a heart patient needs more of the anticlotting coumarin drugs if he is also taking barbiturates to allay his anxiety. The "barbies" hasten the breakdown of coumarin, and they have the same effect on some antiepilepsy and antifungal drugs...
...Paul University in Chicago. Partly because of a punctured eardrum that left him semideaf, he was "shy, diffident, introverted-an exceptionally quiet guy." Six months of study with Composer Paul Hindemith at Yale didn't help matters much; he lost 25 Ibs. and suffered a nervous breakdown. "I couldn't take his Prussian taskmaster tactics," says Bazelon. Bazelon eventually 'fled to California to study at Mills College with Composer Darius Milhaud, and in 1948 decided to strike out on his own. For the next seven years he worked in Manhattan as a railroad reservations clerk and wrote...
...bargain with the druggist the next time we need a prescription? When is the best time to approach an attorney for his lowest fee? When does one get the best bargain from his family doctor on the next baby or an emergency operation? Better yet, perhaps a breakdown on the publishing business is in order...
...cause appears to be the lack of a single enzyme which is supposed to aid in the breakdown of something called isovaleric acid into simpler compounds. If the enzyme is missing, the acid accumulates in the body and a whole chain of chemical reactions is broken...
Thousands of chemical reactions in the body require the aid of enzymes, and the breakdown of any one of them could lead to a disease like this. There are about 30 such conditions now on record, according to Isselbacher...