Word: brinster
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Dates: during 2000-2009
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...getting foreign genes into a living, breathing mouse and then activating them turned out to be extremely tricky. A dramatic success occurred in 1982, when Ralph Brinster of the University of Pennsylvania School of Veterinary Medicine, Richard Palmiter of the University of Washington in Seattle and their colleagues concocted a sort of two-part genetic mongrel. They fused a gene that produces rat growth hormone to a powerful regulatory switch cleaved from a mouse gene. That construct in hand, the scientists mated normal male and female mice, and then removed the fertilized eggs from the female before...
...variety of tissues. These offspring, spurred on by the extra portion of growth hormone, ballooned to twice the size of normal mice. What is more, because the new gene was present in all their cells, including their sex cells, it was passed along to the next generation. Says Brinster: "We're now doing work on the seventh generation of Supermouse...
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