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...debate begins in earnest this week, when the FDA conducts hearings on requests by Merck & Co., maker of Mevacor, and Bristol-Myers Squibb Co., manufacturer of Pravachol, to sell lower-dose versions of their cholesterol-lowering products over the counter (OTC). If the FDA approves the switch, it may unleash a flood of similar requests from other drugmakers...
Merck and Bristol-Myers Squibb say they are pushing for OTC status for their products to make them more widely and cheaply available. But analysts note that Merck's patent on Mevacor expires next year. And while Bristol-Myers Squibb's patent on Pravachol runs to 2005, generic versions of Mevacor will surely cut into Pravachol's sales, justifying Bristol-Myers' push for OTC too. An added benefit: a switch could give the maker exclusive selling rights on the drug for three more years. That's why medicines like the hair-loss treatment Rogaine (owned by Pharmacia Corp...
...paper, and now we had the scissors," says Selkoe. If he is right, one of those scissors, gamma secretase, may actually be the presenilin-1 protein. Whatever the true identity of gamma secretase turns out to be, pharmaceutical companies are rushing to develop drugs that block it. Bristol-Myers Squibb has already started safety tests of one such compound and hopes to expand its study soon...
...while Hollywood goes mad for techno tricks, directors Nick Park and Peter Lord and their team at Aardman Studios of Bristol, England, are still crafting films by hand. Chicken Run is one of the few features made in the sublimely masochistic form of animation known as stop motion, in which plasticine puppets on miniature film sets must be adjusted 24 times for every second of film. A live-action feature has perhaps 500 shots; this 82-min. movie has 118,080. "The detail is astonishing," says Lord, still in awe of his colleagues' industry 28 years after co-founding...
Sujit M. Raman '00 is a Marshall scholar, headed nest year to the University of Bristol to study sociology. Before every success, however, comes a failure. Raman's came in dramatic fashion...