Word: burakoff
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Dates: during 1990-1999
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...three scientists who discovered thatthe molecules called CDFs keep the AIDS virus frombinding to human cells--Professor of PediatricsSteven J. Burakoff, Professor of Medicine RobertW. Finberg and Professor of Chemistry Stuart L.Schreiber--are working to take their discoverybeyond the test tube...
Current experiments include tagging CPFmolecules with radioactive chemicals to betterunderstand how the drug interacts with the virus,Burakoff says. In addition, he says, theresearchers will try to implant both human immunecells and the AIDS virus into mice with no immunesystem, to see whether the CDF molecule reallyblocks the disease from spreading...
...Burakoff agrees, noting that test tubeexperiments don't reveal whether a drug will betoxic to humans, or for how long a drug might beeffective. All three researchers say much researchstill needs to be done...
...team is already working to contractwith a pharmaceutical firm, enabling them tomanufacture and test 50 or 100 differentvariations of the CPF molecule, Burakoff says. Andwhile nobody will offer a timetable, the teamseems optimistic...
...Harvard professors made national news when they reported that they had synthesized a molecule that in laboratory tests had prevented AIDS from spreading. Professor of Chemistry Stuart L. Schreiber, Professor of Pediatrics Steven J. Burakoff and Associate Professor of Medicine Robert W. Finberg say it is too soon to know the drug's potential, and warn that any testing for humans is at least a year away. Nevertheless, Burakoff said the drug "holds out the hope that it might prevent the spread of AIDS...