Word: burkitt
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...severe sore throat during her tour and wondered if she had somehow passed along an infection that caused cancer. Poring over medical books in local libraries, they found no reference to a viral cause of non- Hodgkin's lymphoma. Instead, they came upon another cancer of immune-system cells, Burkitt's lymphoma, which afflicts black African children and is strongly associated with infection by the Epstein-Barr virus. Even though the stricken family is white, says the Georgia victim, "it was the only viral- caused cancer that we could find. Because of that and because of where our visitor came...
...could not establish a general cause and effect relationship between viruses and cancer. Recent advances in the field of genetic engineering have paralleled a surge of interest in the possibility of a genetic cause of cancer. But apart from circumstancial evidence for genetic causes of such rare cancers as Burkitt's lymphoma (as Harvard recently announced), the possibility of finding such a genetic cause for all cancers seems remote...
...some lung cancers a piece is often missing from chromosome No. 3. Better-documented changes occur in certain leukemias and lymphomas. In one form of chronic leukemia, a piece of chromosome 22 changes place with a piece of chromosome 9. In most patients with a cancer known as Burkitt's lymphoma, a piece of chromosome 8 has changed places with a piece...
...these "translocations" might cause cancer has never been known, but the first real insight was announced at the Chicago conference. Researchers representing teams at Harvard and at Philadelphia's Wistar Institute reported that they had analyzed the piece of chromosome 8 involved in Burkitt's lymphoma. Both found that it contained a gene virtually identical to a cancer-causing gene isolated years earlier from a virus. The oncogene is located at the precise point where the fragment of chromosome 8 broke off. Thus the first link has been made between a known oncogene and an easily detectable change...
...also discovered that in a type of cancer called Burkitt's lymphomas, a gene that is apparently associated with annual cancers may be inserted near the spot where authorities are actively produced. The tumor generated may be submitted to a pattern of abnormal growth because of its proximity to the immunoglobulin gene...