Word: cancer
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Dates: during 2000-2009
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...complications from infection or blood clots. While current drug treatments for osteoporosis slow down the destruction of existing bone, the new data suggest that denosumab may be more effective in promoting bone density. In addition, the studies show that denosumab did not cause the serious side effects - including cancer and the disintegration of bone in the jaw - that are associated with bisphosphonate drugs like Boniva, Fosamax and Reclast, the most commonly prescribed osteoporosis drugs on the market. (See TIME's special report "America...
...first study, involving 1,468 prostate-cancer patients receiving testosterone-depleting therapy - which can retard the growth of tumors but increases the risk of brittle bones and osteoporosis - half were given denosumab injections every six months for 36 months, and the other half were given a placebo. Over the course of the three-year study, the treatment group had a 62% lower risk of spinal fracture than the placebo group (1.5% of treated patients suffered a fracture vs. 3.9% of the placebo group) and a 5.6% increase in bone-mineral density in the spine. Patients receiving a placebo...
...results of that study, called the Denosumab Hormone Ablation Bone Loss Trial (HALT), were especially welcomed by cancer doctors, since it was the first study to show that a drug can lower the risk of fractures in men with prostate cancer. So far, most trials of osteoporosis treatments have focused on postmenopausal women, who are at high risk of bone loss with the sudden drop in estrogen that occurs after menopause...
...This really addresses an unmet medical need for fracture prevention in men receiving androgen-deprivation therapy for prostate cancer," says Dr. Matthew Smith, director of genitourinary medical oncology at Massachusetts General Hospital and the lead author of the HALT paper. "Given that we have such little data on fracture prevention in men, these findings are important...
...After Astonishing France, Marie-Laure Dies of Cancer," read the headline of daily Le Parisien's story on Picat's Aug. 9 passing. "The Death of Mother Courage," echoed France Soir. "Marie-Laure Picat: The End of a Battle," observed the website agoravox.fr. (See pictures of cancer survivors' inspirational stories...