Word: cancered
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Dates: during 1940-1949
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...compound called 2,6-diaminopu-rine, not yet isolated in nature, which they thought had a momentary existence inside the cell. The organic chemists synthesized some of this compound and turned it over to the chemotherapists. They thought that it might have the sought-for "differential effect" on lawless cancer cells...
...possibility, even faintly promising, should be neglected. One long shot is to look for something in the secretions of molds. One such secretion, penicillin, has a differential effect on bacteria: it kills bacteria but leaves human tissue unharmed. Molds might conceivably produce something with a differential effect on cancer cells...
...Kettering, various molds (green or white mats) are growing in flasks. The program is still young, but already one mold has been found that secretes a substance with a slight differential effect on mouse tumors. Dr. Rhoads does not even want to talk about it yet. He has no "cancer penicillin...
Then she turned to the deadly virus of Russian spring-and-summer encephalitis, injected it into the abdominal cavity of cancerous mice. In about two days the firm, round tumors turned into blobs of pus. All the cancer cells apparently died. But the virus then went on and attacked the nerves and brain. Four days later the mice, apparently cured of cancer, died of encephalitis. Nonetheless, the virus had shown a dramatic differential effect. It went first to the tumor and thrived there before attacking the brain...
...encephalitis virus on monkeys. The laboratory strain has lived so long in mouse brains that it may have lost its ability to attack primates. If it proves harmless to monkeys, it probably will not hurt humans. The final step will be to try it on human cancer patients to see if it attacks their tumors...