Word: cancerous
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...What was unique in our approach was that we were interested in alterations across different cancer types,” said HMS student Craig H. Mermel. “We want to stop looking at brain cancer or lung cancer but instead diagnose cancer by mutations common to the disease...
...sample of 3,131 cancer specimens of 26 cancer types, the group identified 158 regions of focal somatic copy number alterations (SCNAs) that were frequently altered across several cancer types. Somatic copy number alterations occur when there are abnormal numbers of chromosomes within a tumor’s genome, Mermel said...
Although the exact role of SCNAs is still unclear, the researchers found that a large number of SCNAs identified in individual cancer types are present over several cancers of different origin. The common SCNAs may act as important markers in the diagnosis and treatment of cancer, according to Rameen Beroukhim, a clinical fellow in oncology at Harvard-affiliate Dana-Farber Cancer Institute...
...Each cancer type obviously has a very complicated copy number profile,” Beroukhim said. “Two cancer types individually don’t look that similar, but we found that over such a large number of samples, copy number profiles looked more similar than different...
Matthew L. Meyerson ’85, professor of pathology at HMS, emphasized the shift to viewing the diagnosis of cancer on a genetic basis...