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...Most of the 16,600 women participating in the WHI at centers across the country stopped taking their supplemental hormone therapy after 2002, when the study found that the treatment increased a woman's risk of breast cancer, and did not protect women from heart disease, as doctors had previously thought. But the WHI continued to follow these subjects for heart disease, various cancers, stroke, fractures and other causes of death. They found, to their surprise, that the women who had taken HT for three to eight years had a 12% greater risk of overall death than women...
...Most of that increased risk was due to the greater danger of breast and other cancers among these women. "We had all hoped to see the breast cancer risk diminish rapidly [after hormone therapy was stopped]," says Dr. Gerardo Heiss, the lead author of the JAMA study and an epidemiologist at the University of North Carolina's School of Public Health. "But that was not the case with women...
...While the fact that HT's risks may last longer than any woman would like, doctors stress that this risk is still very small. The overall risk of cancer, for instance, among women taking estrogen and progestin, comes to three extra cases per 1000 women per year. For breast cancer, the study found one extra case per 1000 women per year. "It's helpful to translate the findings into absolute cases," notes Dr. JoAnn Manson, chief of preventive medicine at Harvard's Brigham and Women's Hospital. "So for women who are having distressing menopausal symptoms, who are not sleeping...
...last year with $6 million in donations that came primarily from alumni “who have an affinity toward this area.” The first found of funding—awarded last fall—was geared toward marketable research to combat widespread diseases, such as HIV, cancer, and diabetes. “My personal feeling is that academic researchers can really have significant impact on health care and society by lending their expertise to projects that can be translated into therapeutic intervention,” said Joan S. Brugge, a professor of cell biology who sits...
Researchers from the Harvard Stem Cell Institute (HSCI) and Mass. General Hospital (MGH) are one step closer to reprogramming adult stem cells and making them capable of creating tissues for all parts of the body without the use of viruses or cancer-causing genes. Harvard Medical School professor Konrad A. Hochedlinger recently discovered how long adult mouse stem cells need to be exposed to reprogramming factors before they convert to a pluripotent, embryonic-like state, at which point they can be potentially used for medical treatments. According to Hochedlinger, his lab set out to unveil the mysteries of the reprogramming...