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Heart attack, stroke or cancer. Take your pick. That was the choice I was being offered, or so it seemed. I'm one of hundreds of patients who were participating in clinical trials to investigate whether COX-2 inhibitors such as Celebrex and Vioxx, commonly used as anti-inflammatory drugs, are also effective in fighting or preventing cancer. But the trials were halted last year after reports that the risk of heart attack or stroke doubled among a group of Vioxx users. Vioxx was summarily yanked from the market and the tort lawyers immediately canceled lunch. Celebrex was also implicated...

Author: /time Magazine | Title: My Most Difficult Choice | 5/16/2005 | See Source »

...come to hope-- was a promising avenue of research. That promise was underscored by several papers presented at the annual meeting of the American Society of Clinical Oncology (ASCO) last week, including one out of UCLA Medical School that showed that Celebrex, used in combination with newer cancer drugs, was successful in treating patients with late-stage lung cancer. In 9 out of 15 patients whose prior treatments had failed, the Celebrex cocktail either stopped the disease from progressing or shrank their tumors. In cancer circles, that is an impressive result...

Author: /time Magazine | Title: My Most Difficult Choice | 5/16/2005 | See Source »

Although most of the COX-2 cancer trials eventually resumed, some of the original subjects dropped out, and you can't blame them. There's something screwy about the way the whole COX-2 debacle unfolded. Drugs linked to a relatively small risk of heart attack got pulled off the shelves without apparent concern for the cancer patients whose lives the same drugs might save...

Author: /time Magazine | Title: My Most Difficult Choice | 5/16/2005 | See Source »

Maybe. A study that followed nearly 50,000 men for 15 years concluded that guys age 65 and older who engaged in vigorous physical activity had the same incidence of prostate cancer as inactive men but 70% less risk that their cancer would kill them...

Author: /time Magazine | Title: Doctor's Orders: May 23, 2005 | 5/15/2005 | See Source »

Battling colon cancer two years ago, Washington State's senate majority leader James West, who was at the time also a mayoral candidate, granted an interview to the Spokane Spokesman-Review in which he confided that his illness had brought him closer to his maker. He had come to believe that his supporters' prayers had helped drive back the malignancy. West joked that he imagined God, inundated with requests for his recovery, was barking, "Get me an angel. I need to know who this Jim West...

Author: /time Magazine | Title: Exposed in Spokane, Washington | 5/15/2005 | See Source »

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