Word: cantley
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Dates: during 1980-1989
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...first glance, Herbert Cantley of Huntingdon Valley, Pa., seems an unexceptional 46-year-old man who earns an honest living renovating and painting houses. But that is only his latest career. Last year he was fired from his job as a sales manager at the Philadelphia office of Shearson Lehman Bros., a New York-based brokerage firm, after authorities began investigating % large unreported currency transactions at the company. Last week that investigation finished with a flourish: a federal grand jury indicted Shearson Lehman, Cantley and six other people on charges of laundering $1.2 million for an illegal gambling syndicate...
...count indictment alleges that between September 1982 and July 1985 Cantley and five of his accomplices, including Joseph Vito Mastronardo Jr., the son-in-law of former Philadelphia Mayor Frank Rizzo, operated a $1 million-a-week, five-state gambling ring. They hid their profits, the indictment states, by changing cash into bank checks and money orders, which then made their way into numerous Shearson accounts. The funds were mostly used to buy municipal bonds. Thus the defendants allegedly managed to launder their gambling proceeds by putting them into legitimate investments...
Shearson denied all charges. A prepared statement called the indictment "unprecedented . . . an unfortunate abuse of prosecutorial discretion." The firm said that Cantley was a "disloyal former employee" and that if he and his associates had broken any laws, they did so in "violation of Shearson Lehman's own policies." Through his attorney, Cantley asserted his innocence. If convicted, the former broker could be sentenced to 198 years in prison and fined $16 million...
...exactly the right direction," says Associate Professor of Biochemistry and Molecular Biology Lewis C. Cantley, adding, "Critics say no treatment may ever come out of it, but a good analysis is polio. Much money was spent on the design of a better iron lung machine, but not on the idea of using a serum. With cancer, much less has been spent on clinical treatment, but we may get the breakthrough from a different line of a research...
Once oncagenes are understood, the final step will be to design a drug that inhibits the protein formation process. This, however, may be the most difficult part of the puzzle, Cantley says, since all cells have these proteins, and if they are attacked and destroyed, normal body cells may fall victim to the drugs as well...