Word: caramelizing
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...that it verged on sushi. It was, however, delicious. Dessert, priced between $4 and 6, includes an unfamiliar delicacy called Pastel Basque and a Spanish cheese plate with apples, celery, and red onion marmalade. Pastel Basque turned out to be an Oreo-like cookie crust layered with gooey milk caramel and bananas, and topped with a heaping pile of whipped cream. More fruit and celery would have been nice to complement the sharp cheese, but it was polished off with little complaint. Nota bona--weekends the restaurant serves food until midnight, and Thursdays there is live classical Spanish guitar...
...most of which has been blamed on her? "I'm emotional, but I'm not difficult," she counters. "I'm dramatic, I'm intense, but people like to work with me." Over a table laden with desserts, including le vacherin minute et meringue reglisse and le kouglof glace au caramel, Guarnaschelli confides that she gained 25 lbs. while working...
When foods like turkey, bread and caramel are heated, proteins bind with sugars, causing the surface to darken and, in some cases, turn soft and sticky. In the 1970s, biochemists hypothesized that the same reaction might occur in the bodies of people suffering from diabetes, as excess glucose combined with proteins in the course of metabolism. When sugars and proteins bond, they attract other proteins, which form a sticky, weblike network that could stiffen joints, block arteries and cloud clear tissues like the lens of the eye, leading to cataracts. Since diabetics suffer from all these ailments, the biochemists guessed...
...years since the caramel theory was first advanced, the gooey glycosylation residue has been given an appropriate acronym: AGES, for advanced glycosylation end products. If residue from AGES do indeed gum up the body's works, however, there may now be a way to get things unstuck. Investigators at the Picower Institute for Medical Research in New York are working on a drug that acts as an AGES solvent. Known as pimagedine, the medication dissolves the connections between the AGES protein and the proteins that cluster around it. In one study, 18 patients taking pimagedine showed reduced blood levels...
While none of these therapies would take human beings anywhere near the tripled and quadrupled life-spans achieved in fruit flies and nematodes, they could at least improve our life expectancies--the number of years even our shortened telomeres and caramel-gummed cells would allow us to achieve if illness didn't claim us first. For much of the time our species has been on the planet, that figure is thought to have been a mere 20 years--barely long enough for contemporary people living contemporary lives to move out of their parents' home. The fact that those lives...