Word: cardiovascular
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...fate of the dog samples will depend on Westhusin's work. He knows that even if he gets a dog viably pregnant, the offspring, should they survive, will face the problems shown at birth by other cloned animals: abnormalities like immature lungs and cardiovascular and weight problems. "Why would you ever want to clone humans," Westhusin asks, "when we're not even close to getting it worked out in animals...
...fate of the dog samples will depend on Westhusin's work. He knows that even if he gets a dog viably pregnant, the offspring, should they survive, will face the problems shown at birth by other cloned animals: abnormalities like immature lungs and cardiovascular and weight problems. "Why would you ever want to clone humans," Westhusin asks, "when we're not even close to getting it worked out in animals...
TIES THAT BIND You don't smoke, you're not overweight and your blood pressure and cholesterol check out O.K. And yet, if a family member has cardiovascular disease, the odds are fifty-fifty that your arteries are silently clogging up too. Researchers found abnormal blood flow in 16 of 32 individuals with a parent or sibling who had the disease. The best way to rewrite this family history is aggressive prevention: exercise, diet and, in some cases, medication...
Drugs will play an even greater role in the near future, says Dr. Valentin Fuster, director of the Cardiovascular Institute at Mt. Sinai School of Medicine in New York City. For one thing, the wealth of data coming out of the human-genome project will allow physicians to tailor pharmaceutical treatments to an individual's specific genetic profile in ways that have never before been possible. For another, men and women at risk of developing heart disease are being identified at earlier and earlier stages of their condition, a situation in which drug therapy presents fewer risks than surgery...
...which the body pulls cholesterol that has already been manufactured out of a cell. "By turning this reverse cholesterol transport on, you'd be able to stimulate removal of cholesterol from vessel walls back to the liver for excretion," says Dr. Richard Gregg, vice president of metabolic- and cardiovascular-drug discovery at Bristol-Myers Squibb. Taken in combination with statins, such drugs could virtually sweep the arteries clean of cholesterol...