Word: carinii
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Dates: during 1980-1989
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...introduction of AZT, survival at 18 months jumped to 62.9%. Says Michael Callen, a singer and songwriter who has had the disease for seven years: "We need to change our conception of AIDS. Not everyone dies of AIDS." Today about 70% of all AIDS deaths result from Pneumocystis carinii pneumonia. But studies reported in Montreal confirm that pentamidine inhaled directly into the lungs is dramatically effective in preventing the pneumonia from developing. Federal health officials are so impressed by the drug that they will recommend that those infected with the virus start monthly aerosol treatments as soon as their immune...
...entire system. Nothing illustrates the importance of a healthy immune system more dramatically than the disastrous consequences of its loss. AIDS sufferers become vulnerable to many kinds of invading organisms. Fungal growths corrode the skin and lungs. Normally dormant parasites in the lungs become active, causing Pneumocystis carinii pneumonia. As viruses and bacteria multiply out of control, competing for body cells and destroying them far faster than they can be replaced, victims can be stricken with severe cases of herpes and tuberculosis. What is more, they lose their resistance to some types of cancer, particularly Kaposi's sarcoma...
...Yorker Marberger, the price of that faith is pain, resulting mainly from the experimental drugs he takes, that is so excruciating he must take a "pain cocktail" every four hours. Thus far he has tried interferon, aerosol pentamidine, which is used to treat deadly Pneumocystis carinii pneumonia, and AZT. He has also received dideoxycytidine, an antiviral medication. The treatment left him with tearing facial pains. Last week he was back in the hospital after a bout...
...York report comes at a time when researchers are trying to broaden the definition of the deadly syndrome to include all of the damage that can be caused by HIV infection, not just terminal AIDS. A textbook case of AIDS, involving Kaposi's sarcoma or Pneumocystis carinii pneumonia, represents only the tip of the iceberg. Epidemiologists estimate that for every person with AIDS, there may be as many as ten more suffering from other illnesses caused by the virus. "The real disease starts when you become infected with HIV," says William Haseltine, chief of biochemical pharmacology at the Dana-Farber...
Other presumptive cases are emerging from the past. In New York City in 1959, for example, a 49-year-old Haitian-born shipping clerk fell victim to what today would be a telltale disorder: Pneumocystis carinii pneumonia. "It was so unusual at the time," recalls Dr. Gordon Hennigar, who performed the postmortem and is now chairman of pathology at the Medical University of South Carolina. "AIDS is such a strong possibility that I've often thought about getting the samples and testing them...