Word: castelli
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Dates: during 1990-1999
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...they lose their protection against heart attacks because of a drastic reduction in the female hormone estrogen. That might result in the rapid buildup of plaque on artery walls where, until menopause, very little existed. "When estrogen levels drop, you've just lost your best friend," says Dr. William Castelli, director of the long-running Framingham Heart Study...
Still, most researchers continue to believe that lowering cholesterol levels is the master key to reversing heart disease. Dr. William Castelli, director of the famed Framingham Study, which since 1948 has monitored the coronary health of 5,000 people in the Massachusetts town, offers this prescription for regression: reduce the level of total cholesterol below 150 mg per deciliter of blood and the level of LDL, the bad form of cholesterol that clogs arteries, below 90. In addition, says Castelli, the ratio of total cholesterol to HDL, the good cholesterol that helps clear arteries, should be less than...