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...breakthrough came with his first show at the Leo Castelli Gallery in 1962. Before long his work, as distinct from his personal "image," was the most popular of any Pop artist's. You could pick out his style underwater or a mile away, and it had none of the morbid undercurrent of Warhol's. It was its own logo. It fairly crackled with assertion and impersonality, both at once. Those Benday dots, that studied neutrality of surface, that not-so-simple love of a vernacular (romance and action comics of the '50s) that was already receding into nostalgia when Lichtenstein...

Author: /time Magazine | Title: ROY LICHTENSTEIN: POP'S MOST POPULAR | 10/13/1997 | See Source »

...maybe people shouldn't swill soybean-oil cocktails just because of the Boston University report. "Give me a break," exclaims Dr. William Castelli, director of the Framingham Heart Study in Massachusetts. "This was a very, very tiny study." The observation that heart-disease patients have low levels of essential fatty acids is interesting and deserves follow-up, but it hardly provides proof of cause and effect. In time, perhaps, a more convincing link will emerge...

Author: /time Magazine | Title: Is a Low-Fat Diet Risky? | 9/5/1994 | See Source »

...they lose their protection against heart attacks because of a drastic reduction in the female hormone estrogen. That might result in the rapid buildup of plaque on artery walls where, until menopause, very little existed. "When estrogen levels drop, you've just lost your best friend," says Dr. William Castelli, director of the long-running Framingham Heart Study...

Author: /time Magazine | Title: The Biggest Killer of Women: Heart Attack | 11/9/1992 | See Source »

...larger doses, like those used in early birth-control pills, are known to increase the risk of endometrial and breast cancer. Still, many doctors, considering the even greater risk of coronary- artery disease in the absence of estrogen, now endorse the supplementary therapy. One strong advocate is Framingham's Castelli, who calls the evidence of its efficacy in protecting against both heart disease and osteoporosis "overwhelming...

Author: /time Magazine | Title: The Biggest Killer of Women: Heart Attack | 11/9/1992 | See Source »

Still, most researchers continue to believe that lowering cholesterol levels is the master key to reversing heart disease. Dr. William Castelli, director of the famed Framingham Study, which since 1948 has monitored the coronary health of 5,000 people in the Massachusetts town, offers this prescription for regression: reduce the level of total cholesterol below 150 mg per deciliter of blood and the level of LDL, the bad form of cholesterol that clogs arteries, below 90. In addition, says Castelli, the ratio of total cholesterol to HDL, the good cholesterol that helps clear arteries, should be less than...

Author: /time Magazine | Title: Medicine: Beating Back a Ruthless Killer | 10/29/1990 | See Source »

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