Word: catsper
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Dates: during 2001-2001
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Mice that lack CatSper have sex just as often as normal mice. The mutant males, however, are infertile...
...attempt to find out the exact function of the channel, Clapham and his group tried to insert the gene into mammalian cells that grow in dishes. These efforts failed, implying that the CatSper protein requires other proteins or “subunits” to make it work...
Garbers published a paper in Tuesday’s edition of the Proceedings of the National Academy of Sciences in which he identifies “CatSper2,” an ion channel similar CatSper...
Clapham’s group discovered that CatSper is found only in the part of the sperm cell that connects to the sperm’s tail, or flagellum. This part contains the molecular machinery that allows the sperm to wave the flagellum and move forward...
...paper, Clapham speculated that CatSper could be a target for a new type of contraceptive. If successfully made, such a compound would likely have the benefit of few side effects...